In Taisho-era Japan, Tanjiro Kamado is a kindhearted boy who makes a living selling charcoal. But his peaceful life is shattered when a demon slaughters his entire family. His little sister Nezuko is the only survivor, but she has been transformed into a demon herself! Tanjiro sets out on a dangerous journey to find a way to return his sister to normal and destroy the demon who ruined his life.

The members of the Demon Slayer Corps are sworn to destroy demons wherever they find them-but the condition of Tanjiro's sister, Nezuko, is a problem. What will the Hashira-the leaders of the Demon Slayer Corps-do about Tanjiro protecting his own demonic sister? Meanwhile, Kibutsuji assembles his own minions and intensifies his search for Tanjiro.